Tc-99m decays by isomeric transition and gamma emission with a half-life of 6.01 hours. It is typically produced from molybdenum-99 (Mo-99) generators. Mo-99 is produced in nuclear reactors by neutron irradiation of uranium. The resulting Mo-99 decays to Tc-99m, which is then eluted from the generator. Supply chain considerations involve the availability of nuclear reactors, uranium targets, and Mo-99 generators. Logistical challenges include the transport and delivery of Mo-99 generators and the handling of radioactive materials. Accessibility for developing countries is limited by the specialised facilities and regulatory requirements.
Overview
Maturity
Tc-99m production and application are well-established, with widespread use in nuclear medicine.
Safety considerations
Tc-99m is a radioactive isotope that emits gamma rays, requiring careful handling and shielding to minimise radiation exposure. The short half-life necessitates rapid processing and delivery.
Security considerations
While Tc-99m is not a proliferation concern, proper control and monitoring are necessary to prevent unauthorised access or misuse.
Safeguarding considerations
Traditional IAEA safeguards are not directly applicable due to the absence of fissile materials. However, monitoring and verification of the production and use of Tc-99m may be considered to ensure transparency and prevent misuse.